Predictive value of myocardial performance indices for the detection of significant coronary artery disease in patients with a positive ischemia test

Abstract Funding Acknowledgements Type of funding sources: None. Introduction Echocardiography using conventional global or segmental function evaluation has low diagnostic value in detecting subclinical coronary artery disease (CAD). Deformation parameters are more informative but load-dependent. Myocardial Work (MW) based on non-invasive LV pressure-strain loops been suggested as a new alternative tool for the early detection CAD. Purpose This study aimed to determine MW performance patients with positive ischemia test. Methods Fifty-four referred angiography secondary test were included (43 men (79.6%), mean age: 64.3 ± 9.7 years). Patients divided into two groups according presence (SCAD) absence (NCAD) significant CAD requiring revascularization. Global and measured top echo parameters. Territorial myocardial work index (TWI) constructive (TCW) analyzed angiogram results. Results All had normal wall motion left ventricular ejection fraction. There no differences between regarding echocardiographic deformation. SCAD significantly reduced Constructive (GCW) compared NCAD group (2316 mmHg% vs. 2565 mmHg%; p = 0.012). analysis confirmed decrease TCW segments related SCAD. GCW is parameter largest AUC predict (AUC 0.706; CI 95% (0.56 – 0.84)) high predictive (73.9%). Conclusion impaired territorial quantification allows better discrimination The routine addition those should improve ischemic tests.